Congratulations to our most recent grant awardees!

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FEBRUARY 2019
Kylie Kavanagh, V.M.S, M.V.S, M.P.H., received her first NIH R01 HL142930 (NHLBI) entitled “Adipose Mitochondrial Quality Control and Cardiovascular Function in Metabolically Healthy and Unhealthy Obese Monkeys” The funding is for 5 years in the amount of $697,403.

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Victor Ortega, M.D., received his first NIH R01 HL142992 entitled “Effects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPD”. It proposes genetic studies based on β2AR pathway gene variants and whole-genome studies of rare variants and genetic ancestry to identify novel mechanisms for inter-ethnic differences in drug response and disease severity for asthma and COPD in African Americans. The funding is for 5 years in the amount of $3,796,502.

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John Parks, Ph.D., successfully renewed his NIH R01 HL119962 entitled: “Hepatocyte ABCA1, Cholesterol Trafficking, and Lipid Mobilization”. The goal of this project is to determine: 1) the role of hepatocyte Abca1 in hepatic intracellular cholesterol distribution and trafficking and 2) how genetic deletion of hepatocyte Abca1 reprograms lipid metabolism from an insulin-mediated anabolic state to a catabolic state that reduces hepatic de novo lipogenesis, improves mitochondrial metabolism, and increases triglyceride secretion. The funding is for 5 years in the amount of $3,260,525.

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Tom Register, Ph.D., received a CDMRP Discovery Award entitled “Effects of Ionizing Radiation (IR) on Myocardial DNA Methylation Profiles in Relation to Cardiomyopathy in a Nonhuman Primate Model” The goal of this project is to determine 1) the effects of radiation exposure on myocardial DNA methylation profiles, 2) relationships between myocardial methylation profiles, myocardial fibrosis, and cardiac function, and 3) relationships between myocardial DNA methylation profiles and myocardial transcriptional profiles (funded through another mechanism). The findings will help guide future work to develop biomarkers and interventions for preventing radiation induced heart disease. This award is for 18 months in the amount of $200,000.


FEBRUARY 2019
Reto Asmis, Ph.D., received a Pilot Grant from Center for Redox Biology and Medicine entitled “Redox Regulation of Pyruvate Kinase M2 and Macrophage Polarization”.

Don Bowden, Ph.D., received a CTSI Pilot Grant entitled “Understanding the Contribution of Insulin Resistance to Common Diseases in the Population”.

James Daunais, Ph.D., received a CTSI Ignition award entitled “Conscious Imaging in Nonhuman Primate Models of Human Disease Processes” to further develop conscious MEG imaging in nonhuman primates.

Ellen Quillen, Ph.D., received a CTSI Pilot Grant entitled "Methylation analysis of bone cells to improve high-throughput evaluation of bone marrow composition and gene expression".

Carol Shively, Ph.D., received a CTSI Pilot Grant entitled “Development of Socially Relevant Measures of Nonhuman Primate Cognitive Function Sensitive to Aging and Chronic Disease”.

Xuewei Zhu, Ph.D., received a Pilot Grant from Center for Redox Biology and Medicine entitled “ Pyruvate Oxidation Regulates Canonical and Non-canonical NLRP3 Inflammasome by Targeting Redox Pathways”.


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CENTER FOR PRECISION MEDICINE ANNIVERSARY PARTY
DECEMBER 17, 2018
On December 14, 2018, the Center for Precision Medicine held its first Anniversary Party. More


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CENTER FOR PRECISION MEDICINE ANNUAL POTLUCK AND GIFT EXCHANGE
DECEMBER 12, 2018
On December 4, the Center for Precision Medicine held their annual potluck holiday party. More


fall 2018 grant awardees!

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A. Bishop, Ph.D.

A. Bishop, Ph.D.

DECEMBER 11, 2018
Andrew C. Bishop, Ph.D. - 2018 Innovation Grant Award, Lung Cancer Initiative of North Carolina, $25,000.
Title: “Identification and characterization of novel exhaled breath metabolic signatures of lung cancer”. The Inaugural Vicky Amidon Innovation Grant in Lung Cancer Research Award is for innovative lung cancer projects that will improve the lives of those diagnosed with lung cancer in North Carolina. More

Angelica Riojas

Angelica Riojas

DECEMBER 06, 2018
Angelica Riojas,
PhD student in the Molecular Medicine and Translational Science Program at Wake Forest University, will participate in the 2019 Yale Ciencia Academy. The program helps in developing skills important to further career advancement, and communities through science outreach. Read more.

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SEPTEMBER 30, 2018
Drs. Laura Cox, Michael Olivier, Biswa Misra, Sobha Puppala, And Ellen Quillen receive NIH U19 titled Womb to Tomb: Developmental Programming and Aging Interactions in Primates”. It studies normal aging in primates and the impact of developmental programming on aging; includes scientists from University of Wyoming (Dr. Nathanielsz, Dr. Li, Dr.  Jerow), UT Health San Antonio (Dr. Clarke, Dr. DeFronzo, Dr. Fox), and Texas Biomedical Research Institute (Dr. Lanford).

SEPTEMBER 28, 2018
Drs. Michael Olivier (PI) and Hector Guillen (CO-I) receive $1.99M 4-year R01 (NIGMS) titled “HyCCAPP: A new method for the functional analysis of regulatory SNPs” Collaboration with Drs. Nobrega and Gilad at the University of Chicago,

September 10, 2018
Drs. Beth Kerr, Ph.D., and Ellen Quillen, Ph.D. receive ELSA U. PARDEE Foundation Grant (1 year);
titled “Profiling Cell Composition and Methylation in the Bone Pre-Metastatic Niche”. Read more.

September 6, 2018
Ellen Quillen, Ph.D., receives 3-year NIH/NIA K01 AWARD

Dr. Ellen Quillen, Ph.D., Assistant Professor in the Department of Internal Medicine/ Molecular Medicine, received K01 Award from the National Institute of Aging of the NIH entitled "Integrative Multi-Omic Investigation of Age-Related Changes in Trabecular Bone”. Read more.

September 6, 2018
Liang Liu, Ph.D.,
CPM member and Assistant Professor in Cancer Biology, received a Developmental Research Award from the MD Anderson Cancer Center Specialized Program of Research Excellence (SPOREs) in Uterine Cancer entitled “Mutations in TP53 Underlying Aggressive Endometrial Cancer in African Americans”. More


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August 20, 2018
DEAN'S RESEARCH SYMPOSIUM
The Center for Precision Medicine and the Section on Molecular Medicine jointly presented the Dean's Research Symposium on August 20, 2018. The Symposium featured 10 presentations on a wide range of  current and future research projects predominantly by junior faculty members. More


August 10, 2018
FIRST SUMMER UNDERGRADUATE INTERNS COMPLETE PROGRAM AT THE CENTER FOR PRECISION MEDICINE
On August 10, 2018, our six summer interns completed their 10-week research program in the Center for Precision Medicine with a Poster session. They also presented individual scientific talks. Click here for more information.


TOPS leaders meeting at wake forest University

July 30, 2018
On Monday, July 30, Rick Danforth, the President of Take Off Pounds Sensibly (TOPS), and Dr. Barbara Cady, former President of TOPS and current Advisor to the President of TOPS, visited Wake Forest Baptist Health and the Center for Precision Medicine to participate in the Center for Precision Medicine Obesity Symposium "Obesity Management, Weight Loss, and Prevention”. TOPS is a non-profit weight loss organization that has supported research into the genetics of obesity for the past several decades. Speakers at the Symposium included Dr. Olivier, Dr. Barb Cady, Dr. Joseph Skelton, Director of the Brenner FIT Program, Dr. Kristina Henderson Lewis, Member of the Wake Forest Weight Management Center, and Dr. Barb Nicklas, Member of the Sticht Center for Healthy Aging. The goal of the Symposium was to provide an overview of ongoing obesity-related research efforts last Wake Forest School of Medicine, and explore opportunities how TOPS may be able to assist with some of our ongoing weight loss and management programs, and support research initiatives.


2019 Center for Precision Medicine Summer Picnic

July 28, 2019

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On July 28, 2019, our Center held their first annual summer picnic at Triad Park in Kernersville. Families enjoyed good conversation, many entertaining games, face painting, and a delicious barbecue.  Everyone had a good time and in wonderful sunny weather. Hope you will be able to join us next year!


press release:

March 18, 2018
Dr. Sobha Puppala's press release on recent publication:
Combating childhood obesity by preventing “fatty liver” in fetus.
Full article: Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation

press release:
New Center for Precision Medicine opens at Wake Forest School of Medicine in December 2017

December 2017
This new Center, lead by Dr. Michael Olivier, expands omics-related capabilities at Wake Forest and complements the expertise in precision medicine in the Comprehensive Cancer Center and other research centers of excellence.


Recent Publications

(Click on citation to read publication)


Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation. Sobha Puppala , Cun Li, Jeremy P. Glenn, Romil Saxena, Samer Gawrieh, Amy Quinn, Jennifer Palarczyk, Edward J. Dick Jr, PeterW. Nathanielsz and Laura A. Cox

Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.
Sobha Puppala , Cun Li, Jeremy P. Glenn, Romil Saxena, Samer Gawrieh, Amy Quinn, Jennifer Palarczyk, Edward J. Dick Jr, PeterW. Nathanielsz and Laura A. Cox



Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions. Langefeld, Carl D.  et al.

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions. Langefeld, Carl D. et al.


The non-human primate kidney transcriptome in fetal development. Spradling Reeves  et al.

The non-human primate kidney transcriptome in fetal development. Spradling Reeves et al.


Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status. Andrew C. Bishop, Mark Libardoni, Ahsan Choudary, Biswapriya Misra, Kenneth Lange, John Bernal, Mark Nijland, Cun Li, Michael Olivier, Peter Nathanielsz, and Laura A Cox

Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status.
Andrew C. Bishop, Mark Libardoni, Ahsan Choudary, Biswapriya Misra, Kenneth Lange, John Bernal, Mark Nijland, Cun Li, Michael Olivier, Peter Nathanielsz, and Laura A Cox

Integrated Omics: Tools, Advances, and Future Approaches. Biswapriya B. Misra, Carl Langefeld, Michael Olivier, Laura A. Cox

Integrated Omics: Tools, Advances, and Future Approaches. Biswapriya B. Misra, Carl Langefeld, Michael Olivier, Laura A. Cox

High‐resolution gas chromatography/mass spectrometry metabolomics of non‐human primate serum. Misra, B.  et al.

High‐resolution gas chromatography/mass spectrometry metabolomics of non‐human primate serum. Misra, B. et al.

Maternal obesity has sex dependent effects on insulin, glucose and lipid metabolism and the liver transcriptome in young adult rat offspring. Lomas-Soria  et al.

Maternal obesity has sex dependent effects on insulin, glucose and lipid metabolism and the liver transcriptome in young adult rat offspring. Lomas-Soria et al.

Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study. Raffield LM, Cox AJ, Criqui MH, Hsu FC, Terry JG, Xu J, Freedman BI, Carr JJ, Bowden DW. Cardiovasc Diabetol. 2018 May 11;17(1):67. PMC5946410.

Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study. Raffield LM, Cox AJ, Criqui MH, Hsu FC, Terry JG, Xu J, Freedman BI, Carr JJ, Bowden DW. Cardiovasc Diabetol. 2018 May 11;17(1):67. PMC5946410.