Center for Precision Medicine Recent Grant Awards
1U54DA049113-01 (PIs) Michael Olivier, Tim Howard, Carl Langefeld“Integrated Omics Analysis of Pain: Omics Data Generation Center” 09/01/2019 – 07/31/2023
R21 CA227709 (PIs) Wadas/ William Gmeiner “Adtamer-based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer” 07/01/2019 – 06/30/2021
R01 HL111527-06 (SUB) Victor Ortega “Non-coding RNA Structure Change in Chronic Obstructive Pulmonary Disease” 08/15/2019 – 04/30/2023
1R01 HL146818-01A1 (CO-I) Andrew South“Uric Acid, Klotho, and Salt Sensitivity in Young Adults Born Preterm” 08/15/2019 – 07/31/2024
Letter from the Center Leadership:
The first year of the Center was very successful, and we have all of you to thank for that. Your participation, involvement and enthusiasm made all of this possible! Hopefully, this initial success is just the beginning, and we look forward to expanding our collaborations and interactions with all of you to further advance science and biomedical research here at Wake!
What is the Center for Precision Medicine about?
Welcome to the Center for Precision Medicine at Wake Forest School of Medicine. The Center was launched in December 2017 to foster collaborative interdisciplinary research into the causes of common human disorders, such as heart disease, diabetes, obesity, and other aging-related morbidities. The Center promotes the use of state-of-the-art technologies in genomics, proteomics, metabolomics, and computational biology to explore the biological mechanisms underlying these disorders to improve diagnosis and treatment of patients.
In current clinical practice, we will usually diagnose most chronic diseases once they have already significantly impacted the overall health of a patient. As a result, treatments may slow disease progression and reduce the severity of disease-related health complications, but they do not reverse the impact of these diseases on our long-term health.
The focus of our research efforts is to identify and understand the early molecular changes in our cells and organs that precede the development of clinical symptoms of these diseases. These molecular indicators of health status and health trajectory will help identify individuals at risk for health complications very early in disease progression and open the door for development of targeted, preventive treatments to correct the health trajectory early, allowing patients to live long healthy lives.
Understanding these early molecular changes will also provide new opportunities to develop more targeted treatments with fewer side effects and higher efficacies to improve the lives of patients already affected by these diseases.
Metin Gurcin, PhD & Brian Ostasiewski, BS Dept. – Internal Medicine, WFSOM “Biomedical Informatics and Translational Datawarehouse Resources for Informatics Research” at Biotech Place 155A/B 9/12/2019 10 AM
Shannon Macauley, PhD Dept. Gerontology & Geriatric Medicine, WFSOM “I have microarray data. Now what do I do?” at Biotech Place 155A/B 9/12/2019 10 AM
Regenerative Medicine Meets Precision Medicine Date: October 4, 2019 (9am-3:30pm EST) Location: Richard H. Dean Building 2nd Floor (250A/B)